The bacterial sepsis among neonates increases the cost of medical care, as it causes severe morbidities and therefore increases the length of hospitalization in neonatal intensive care units (NICU) (1, 2). Neonatal sepsis accounts over 50% of the neonatal deaths (3). Early-onset sepsis among neonates is caused by organisms in the birth canal either when the amniotic membranes rupture or leak prior or during the delivery (4). In contrast, late-onset sepsis in neonates might be acquired from the environment (1). Previous studies reported that, medical laboratory scientists and clinicians have faced challenges to recognize the neonatal septic (5). Accordingly, septic neonates must be diagnosed rapidly for taking the right antimicrobial medications (5-7). Moreover, some laboratory investigations should be done such as blood culture and platelet count to alleviate the medical complications of this illness (6, 8). Low platelet count and coagulopathy may be found in most patients with sepsis and subsequently encountered as important complications among septic neonates (9). In septic neonates, haemorrhagic diathesis emerges following DIC as a result of overconsumption of thrombocytes and coagulation factors (10, 11) In the neonatal stage particularly in the ill newborns, thrombocytopenia is encountered as one of the common haematological problems. This occurs predominantly among premature babies and neonates admitted in neonatal intensive care units and usually indicate an underlying pathologic process (10).The current study aimed to detect the effect of sepsis on circulating thrombocytes among Sudanese neonates in correlation with bacteria type and to know the rate of mortality and morbidity among septic neonates.