Stroke treatment aims for immediate reperfusion of the ischemic brain, and research is ongoing to find a medicine that might induce artery recanalisation more fully and with fewer side effects. The important studies that have verified the use and safety are covered in this review article. Other thrombolytic and anticoagulant medicines such as tenecteplase, desmoteplase, accord, tirofiban, abciximab, eptifibatide, and argatroban are also evaluated for safety and efficacy. Tenecteplase and desmoteplase are plasminogen activators that have a stronger affinity for fibrin and a longer half-life than alteplase. In preliminary trials, they demonstrated higher reperfusion rates and improved functional outcomes. Argatroban is a direct thrombin inhibitor that is used as an adjuvant to intravenous TPA and demonstrated greater rates of full recanalisation in the ARTTS research, with additional studies presently underway. Adjuvant thrombolysis procedures utilising transcranial ultrasound are also being researched, and have shown greater rates of full recanalization, as seen in the CLOTBUST study. Overall, medicinal therapy for stroke are significant because they are easier to administer than endovascular procedures, and novel medicines such as tenecteplase, desmoteplase, and adjuvant son thrombolysis are showing promising effects and await larger-scale clinical trials.