Albeit generally uncommon in Canada and the United States, essential liver disease is a typical danger around the world. It positions as the eighth most regular malignant growth, representing 4% of all recently analyzed tumours in both genders. The prevailing type of essential liver malignant growth is hepatocellular carcinoma (HCC). Most other essential liver malignant growths are cholangio carcinomas, which are histologically and etiologically unmistakable from HCC. In the United States, HCC comprises 70% to 75% of instances of essential liver disease. In most high-hazard locales (East and Southeast Asia, and sub-Saharan Africa), well over 90% of essential liver can-cers are HCCs. Special cases are zones with high disease paces of liver accidents (Clonorchis sinensis, Opisthorchis viverrini), which are built up etiological operators of cholangiocarcinoma. In a region in upper east Thailand where O viverrini disease is endemic, 90% of essential liver malignant growths are cholangio carcinomas.