Neurocysticercosis is a worldwide public health problem. It is the most important parasitic infection of the Central Nervous System (CNS) and one of the most common causes of secondary epilepsy in many endemic countries . Also, epilepsy has a median lifetime prevalence of 15.8/1,000 in Latin American countries, and a median incidence of 138.2/100,000. Higher NCC estimates are associated with increased prevalence of epilepsy, pointing out to the need to improve our knowledge of the disease as a potential means to decrease epilepsy prevalence . Although the flux of immigrants to developed countries has led to cases being reported in the United States and other firstworld countries , its presentation in these locations is usually due to immigration from endemic countries instead of local transmission , and its prevalence is 0.2-0.6 per 100 000 inhabitants in some regions of the USA . Diagnostic criteria by Del Brutto and cols have been published in 2001, and a set of revised diagnostic criteria have been released in 2016, aiming to simplify definitions and facilitate its applicability. Greater emphasis has been given to the need of neuroimaging. However, there are several pathologies that can present with similar or even indistinguishable characteristics. Here, we present a set of 5 cases of pathologies that mimicked NCC, described as potential differential diagnosis. All patients were inhabitants of an endemic region and presented with epilepsy.