Retinal diseases are identified as an important cause of ocular morbidity and visual impairment globally. In this Taiwan nationwide cohort study, there was a 1.15- fold increase risk of developing newonset retinal diseases for incident nontyphoid salmonellosis (NTS) patients, compared with the matched controls. Furthermore, Stratified analysis showed that the associated risk of the investigated outcome was significant aged than 61 years old (aHR 1.64, 95% CI = 1.04 to 2.58), in patients with hypertension (aHR= 2.10, 95% C.I. =1.38, 3.2), diabetes mellitus (aHR= 2.05, 95%C.I. = 1.15, 3.65), and hyperlipidemia (aHR= 2.05, 95% C.I. =1.22, 3.45).