Cancers of the uterine corpus are the most common gynecologic cancers in the United States with incidence and mortality increasing both in the United States of America and globally [1,2]. Most uterine cancers have a favorable prognosis and are cured by surgery alone. Identifying patients at risk of recurrence, particularly those misclassified as low risk by current clinicopathologic standards [3-9] is of paramount importance. Physicians need better risk stratification tools to identify when and which adjuvant therapy will decrease recurrence. Validated biomarkers with prognostic, predictive, and/or theragnostic value will likely play a vital role in advancing assessments of risk and guiding clinical management decision making.