Still, numerous questions remain concerning the part of NGF in announcement. Situations of the low- affinity receptor for NGF appear to be at least stable in announcement rudimentary forebrain, and the recent finding of announcement- related increases in cortical NGF brings into question whether endogenous NGF situations are related to the observed cholinergic atrophy and whether fresh NGF will be useful in treating this complaint. Substantiation regarding the localization of NGF within the central nervous system and its presumed part in maintaining rudimentary forebrain cholinergic neurons is epitomized, followed by a synopsis of the applicable aspects of announcement neuropathology