Nanoparticulate drug delivery has become an area of extensive research as these systems enable bioavailability improvement of poorly water-soluble compounds as well as targeted delivery of active pharmaceutical ingredients to various tissues and organs. Generally, nanoparticles in drug delivery are defined as submicron colloidal particles ranging from 10 to 1000 nm3. The US Patent and Trademark Office, however, define nanotechnology using a scale from only 1 to 100 nm and slightly larger.