Methicillin-resistant as one of the main culprits causing nosocomial and community infections, Staphylococcus aureus (MRSA) infection in humans and animals is alarming. Additionally, there are few therapeutic alternatives due to MRSA's slightly rising medication resistance. This study focuses on determining the incidence of MRSA in shrines, an environment where frequent interactions between people and animals might spread diseases, genes, and germs that are resistant to antibiotics. Between March 2018 and May 2018, 120 environmental swabs were collected from specific locations. Gram staining, standard biochemical testing and growth on mannitol salt agar (MSA) were used to identify Staphylococcus aureus and MRSA, respectively. The disc diffusion method was used to assess the antibiotic susceptibility of S. aureus isolates. Methicillin-sensitive S. aureus (MSSA) and MRSA proportions were 19% and 81%, respectively; isolates from Thapathali had a high prevalence of MRSA (28.6%). MSSA isolates exhibited a high level of erythromycin resistance (64.7%). The MRSA isolates tested negative for ciprofloxacin (25%), erythromycin (50%), gentamicin (50%), and cotrimoxazole (25%). Linezolid (100%), clindamycin (100%), ciprofloxacin (75%), erythromycin (50%), tetracycline (100%), and cotrimoxazole (75%), among other antibiotics, were all effective against the isolates. Gentamicin (50% resistance) also exhibited intermediate resistance. Inducible clindamycin resistance (ICR) was present in 6 (54.5%) of the 11 MSSA isolates that were both erythromycin- and clindamycinsensitive. It was also present in 2 MRSA isolates that were both erythromycin- and clindamycin-sensitive. Only two MRSA isolates produced -lactamase, as opposed to fifteen MSSA isolates that were -lactamase positive. Only a little amount of study has been done on infectious diseases that affect both primates and animals. This study reveals that MRSA/MSSA is widespread in the shrines, which may be a key location for infection transmission between people and monkeys.