Blood borne infections pose a serious threat to health and wellbeing of health care workers in Egypt. Hepatitis B, Hepatitis C and HIV have in common the blood borne pathway of transmission and severity of their outcome .Occupational health and safety aims at prevention of such transmission at different levels eg vaccination prevention for Hepatitis, post exposure prophylaxis and follow up after exposure. Also OSHA’s final rule made it mandatory that health care facilities assumed responsibility for protection of their employees from exposure to Blood borne pathogen by eight components such as person protective equipment , universal precaution , engineering control , work practice control , Hepatitis B prophylaxis training and education record keeping . The aim of this study was to design a blood borne pathogen control plan for Mansoura University Hospital through assessing nurses knowledge and awareness related to Blood Borne Pathogen control , assessing the viability of equipment and supplies in various department in the designated hospital , designing the blood borne pathogen control plan based on the assumed data , and examining the validity of the designated plan .