Growth Arrest Specific 6 (Gas6) is a vitamin K-dependent protein [1], the biological activity of which is mediated by TAM receptors, a family of Tyrosine Kinases which includes three different members: Tyro3, Axl and Mer [2]. TAM receptors are also activated by Protein S [3], which shares structural similarities with Gas6, but is mainly expressed in the liver and exerts an anticoagulant effect in vivo [4]; conversely, Gas6 is more widely expressed (lung, heart, kidney, intestine, endothelial cells, bone marrow, vascular smooth muscle cells, monocytes and liver) [5,6] and has much more pleiotropic effects. Gas6/TAM seems to be particularly relevant in the regulation of immune system, raising interest in its potential involvement in autoimmune diseases [7]. First of all, Gas6 mediates the recognition of apoptotic bodies (AB) by TAM receptors, acting as a bridge between phosphatidylserine on external cell membrane of AB and TAM receptors expressed by phagocytic cells [8,9]. A defective TAMmediated phagocytosis has been claimed as potentially relevant in the development of autoimmunity conditions, such as Systemic Lupus Erythematous (SLE) [10]. Furthermore, it has been shown that Gas6/TAM system plays a major role in switching off inflammation [11], by inducing the expression of the suppressor of cytokine signalling proteins SOCS 1 and 30 [12]; Gas6 is also able to suppress IL-1, IL-6 and TNFα expression by TLR-activated monocytes/macrophages via activation of PI3K/Akt pathway and inhibition of NF- κB nuclear translocation