Metosartan induces numerous deleterious effects in male Wistar rats treated with drug and RNase. It causes pre maturation of sperms and reduces the sperm count as well as reduces viable sperm count. It induces the xchromosome desynapsis resulting in testicular carcinoma. The effects are so profound just in case of drug than compared to the enzyme RNase. Metosartan induces apoptosis in testicular tissue mainly through intrinsic pathway which is especially thanks to genotoxic agents. The drug mainly inhibits RNase A in rat testes and has positive effect on Mitosis.