: Mesenchymal stem cells (MSCs) are getting increasingly critical because of the large spectrum of trophic and immunomodulatory factors they secrete. The MSC secretome plays a position in angiogenesis and revascularization, immune modulation and tissue restore; however, there's a lack of strategies suitable for controlling this effect. Evidence exists to show cellular substrates have an impact on MSC behaviour. Therefore, manipulating the cellular substrate may want to provide stepped forward techniques for controlling the secretome for brand spanking new treatment plans but there may be presently a loss of cell substrates suitable for implantation.