This research looks at parent-adolescent communication on sexual issues and HIV prevention at Otjomuise clinic in Windhoek-Namibia. The literature review showed that parent-adolescent communication about sexual issues and HIV prevention is rare especially in Africa because of lack of skills, information and cultural beliefs. The aim of the study is to investigate parental communication with their adolescents about sexual issues and HIV prevention. The Specific objectives were: To investigate whether parents communicated with their adolescents on sexual issues and HIV prevention. To explore type of information that was communicated. To determine challenges encountered in communicating with their adolescents. To seek suggestions from parents on how to improve communication between parents and adolescents regarding sexual issues and HIV prevention.